All I have ever loaded 10mm with is Longshot. I can tell you people (say maybe at a certain 10mm site) go over book with regularity. I am NOT recommending this in any way, shape or form, I'm just saying starting at 7 grains would not produce any over pressure. You don't say what gun, but 6.5gr would be very conservative, most likely would produce some decent plinking rounds but may be a little weak for some AR carbines and Glocks with 20#+ springs. Most likely would function with stock Glock springs and S&W 1006, and most 10mm 1911's.