somoss,
First welcome to THR
New shooters are surprised at the strength of recoil, the brightness of the muzzle flash, and especially the loudness of the sound of real guns. As you shoot more, you will get more accustomed to all three aspects. The flash and sound blast will startle you less and the recoil will be easier to deal with as your grip technique improves. Now a .45 or even a 9mm may seem too kicky, but that will pass with practice.
The Ruger .22 pistols are excellent and a lot of fun to shoot, but I doubt their educational value. The problem is they are relatively light and have virtually no recoil, so I do not think they prepare one well for the bigger calibers. It is easy to get good with them fast, but their defensive value is quite low. In essence, they are like tricycles before motorcycles - may be good to practice steering, but in the long run superfluous.
So, if you have more money to spend, go for both a .22 pistol (I recommend Ruger MkII or III with long barrel) and another in a serious caliber (I recommend a quality full-size reliable 9mm, e.g. Glock 17, Ruger P89, Beretta 92FS). If you don't have that much to spend, I recommend skipping the .22 and going for the serious caliber only. But, before you purchase any gun, I recommend you do the following:
Ammo for .22 is very cheap and you can just rent a .22 at the range and shoot a lot to pick up the very basics fast. Once you feel comfortable with the .22, rent a dozen guns in the serious calibers and try them out. Figure out if you prefer revolvers or autoloaders, then consider how much you can afford to spend on practice ammo. If ammo expense is a concern, you may want to go for 357 revolvers to shoot 38sp, or go for 9mm autoloaders. Once you set the platform type and caliber, this quickly narrows down your choices. Put in the price range as a limitation and that will narrow them down further. Next, educate yourself about the platforms that you heard good things about and liked in your hand at the range. Narrow down to maybe three platforms and ask about them at THR. Finally, check the local laws about what you are allowed to purchase in your state, city, etc. (e.g. here in PRC, they don't allow import of Walther PPK and others
). At the end of this process, the choice will be obvious and you will feel content and secure in your decision.
Good luck!