I always recommend a 4" 686+ as the ideal home defense weapon for those who do not want to spend time at the range, and for those who do. Accurate reliable, choice of different power levels for ammo, something no semi auto can duplicate with 100% reliability. If the person is unable to pull the da trigger or cock the hammer, they will not be able to rack the slide on many semi autos. Take her to the range and rent one for her to shoot with.38 spl. There are lots of good reduced recoil .38 and +p as well as full magnum loads availible.
Btw both my children son and daughter, were able to shoot my 686 and my K22 Double action when they were 8 years old.
If she like the Kimber make sure she can rack the slide, this may take practice, and understands the operation of the firearm.
I have recommended the Glock G26 also to a couple of new female shooters who did not want a revolver (they see semi autos in the movies). It is simple and reliable, easy to shoot well, and not too hard to operate the slide.