TG: burns very HOT. Very fast. Throws pressure spikes. Got popular with action pistol shooters because it is fast, available, and works OK at small charge weights. Best for very light target loads at starting loads or a bit less. I have not found it any where near as accurate as Bullseye, Red Dot, AA2, or 231/HP38.
AutoComp: designed to produce a lot of gas, so compensators work better; so, if you are shooting open-class compensated guns in 9x19, 9x21, or .38 Super, it may be the best thing since sliced bread. It is much slower than TG and is best for cartridges working at 25ksi and higher and mid-range to MAX charges.
It, along with Silhouette, BE-86, and Power Pistol will do well in 10mm Auto, but not likely to produce the high velocities of AA7 or AA9.
Open any of your many loading manuals and you can see how the two compare.