I read Masaad Ayoob's original article in Handloader claiming that he had seen attorneys try to make an issue out of use of handloaded ammo. He claimed it was a nightmare in court.
Ayoob did allow that if you loaded down, like say loading a .44 mag to 1200 fps or so, you could actually turn the argument to advantage, by saying the gun was too hard to control with hot loads, and you felt it was powerful enough as is.
Remember, you shoot bad guys to stop serious crimes, not to make social statements. Your only aim is to stop the crime. Whether or not he dies is a non-issue at the moment you shoot.
On the flip side of the coin, Sheriff Jim Wilson has reportedly done a study, and could find no case where it actually became an issue. I didn't read his article, though, but I did read Ayoob's.
As a practical matter, though, for defensive use, do you want reused cases, or brand new? It doesn't much matter in a revolver, but it does in the auto. Reloaded cases, even those carefully loaded, can have burrs or unoticed problems that harm reliability at the worst possible time.
I do keep Federal Hydra-Shoks in my full size .45's. They are known to work well, and are reliable and accurate, so I don't think I'm giving up anything. My Colt Defender so far seems to run best with my handloads, so if I CCW it I may just carry accordingly.