No less a person than the late great Bill Jordan, multi-gunfight veteran, retired from the US Border Patrol, author of _No Second Place Winner_, who prompted S&W to produce the Combat Magnum, also urged S&W to produce an Airweight J-frame chambered for the .22 WMR. Of course, the Combat Magnum, later to become the truly great Model 19 and Model 66, happened MUCH sooner than the little 351PD.
My normal minimum carry gun is an SP101, and I usually pack larger, carrying on my own time the same personally-owned P229 duty pistols that I use at work. The 351PD, however, may be what finally calls me to regularly tote a mousegun, at least for backup. No, it is not a rifle, but just as a .357 mag from a short barrel will have more energy than a .38 from the same barrel, the WMR will have a bit more punch than the LR when the bore size is .22, and with the 351PD, there are quite a few of them.