"You should never tumble loaded ammunition as it will alter the grain size of the powder and make a dangerous condition".
Ok, I've seen this myth and believed it at one point, but this is the only way I know to massivley remove case lube from cartridges after loading them on a progressive press. I've done this with pistol and rifle ammo and had no noticable difference in pressures, performance, or velocity. Powder is a lot harder than you think and when shipped from the factory, on train and truck to your location, will jar it as if it were in a tumbler, and it never seems to have an issue, why would 15 mins in a vibratory tumbler make a difference?
I have heard of powder duplexing. Usually it is something done for large capacity cases that are going to be used in very cold weather where ignition may be a problem. A lot of very slow burning powders don't ignote well in cold weather and I have read of instances where you trickle a couple of grains of easily ignited fast burning powder near the primer, and then follow with a full charge of the slow burning stuff. These are usually nearly full or compressed loads of powder so there is little room for the faster stuff to shift. With the invention of powders that are not temperature sensitive, this kind of thought has gone by the wayside though.
Vince