If you're shooting a ball, the ROA will hold about 40-45 grains of powder. I've heard of people shooting as little as 15 grains accurately, but they needed to use cornmeal. Just subtract your powder charge from 40, and add the difference in meal. For example, if you're shooting 15 grains of powder, load in 25 grains (by volume) of meal on top of that for proper compression with the stock load lever and round ball.
Some have told me that meal compresses more than BP itself, so you may want to throw an extra five grains in there to be sure. Ideally, after you ram it all down, the ball should be about 1/16" down from the opening/lip of the chamber.