My advice: if you can't get the EZ grip safety to work reliably for you, please don't blame this on the gun.
Simpler is better when it comes to operating a pistol for self defense. I want to have to correctly do as few things as possible. I also like a pistol that can operate normally even if the gun is gripped in less than ideal position. All autos are going to be dependent on grip of course, but some more than others.