Unless you can envision a situation (with a high probability of occurrence) in which a hot .45 ACP or 10mm auto round would NOT be likely to suffice, I'd carry a semi-auto in one of these calibers. A .45 ACP loaded to the edge propels a 200 grain projectile at about 1000 f/s. The 10mm exceeds that by about 100 f/s. The .41 and .44 Mags will beat the 10mm's velocity by ab0ut 200 f/s, and will handle heavier projectiles better than either of the autos.
But the revolvers do so at the cost of more weight, smaller capacity, slower reloads, and greater bulk. If I was in a part of the world where encountering a bear, agitated moose, or creep wearing a ballistic vest, I could make a case for carrying a large magnum revolver as a reactive/defensive arm. Otherwise, I'm inclined to carry my 1911A1.