I tend to piddle and experiment till I find the perfect loads for each gun. For example I found that 4 grns of unique and a 88 grn Jhp works perfectly in the 380 auto. No more experiments there, just keep loading them. Same thing for 45 acp. 4.9 grns of bullseye, 230 grn hardball. Works perfect and I just keep shooting them.
The rest of the rounds are just a steady run of experiments.