Well, since ergonomics is such a personal & subjective issue, you'll have to answer that question for yourself after handling a lot of different pistols ...
I only know one man who currently carries a P245. He was previously carrying one of the smaller Colt 1911 variants, but just didn't feel "comfortable" with cocked & locked, especially for rapid presentation. He wanted to remain with a .45 ACP, though ...
A relative of his is presently deployed in the Teams, and recommended he try a Sig P245. When he asked for my recommendation, I asked for a little more detail on exactly WHY he felt uncomfortable with the small 1911's, and WHAT he was looking for when it came to a defensive pistol ... other than caliber. He basically seemed to want something that was lightweight, compact, didn't require any manipulation of external safeties ... and "felt better" than a Glock, both in grip and trigger action. He didn't seem to prefer the size and overall ergonomics of either the compact S&W's or the HK's ...
I agreed he should try the little Sig on for size ... and when he did, he immediately liked it. It replaced his little Colt as his CCW weapon, and he's been very happy with it since then ...
Now, this is a fellow that is willing to spend the money necessary to obtain the "best" CCW weapon for his requirements ... and someone that doesn't "enjoy" spending time at a range for recreation, either. He just wants a defensive weapon chambered in .45, that "fits" him, and is easy to use (for him) under stress.
I think he probably chose wisely ... even if I wouldn't personally spend the money on a Sig ... I think they've always been over-priced ... and I shoot other designs "better" ...
Try one out and see what YOU think of it ...