It depends on what you really want.
If you are looking for authenticity and the "Real Old West" or you are leaning towards CAS shooting, then a Pietta 1873 in .45 Colt is a good choice. These are less expensive than the equivalent Uberti 1873 replica, yet the newer production ones are very nice looking, well made, and very good value. .45 Colt is the original caliber and was highly popular, although you can have .357 magnum if you prefer.
(Check out Duelist1954 on You-Tube for many videos, reviews, and advice/how-to about old west guns including Pietta.
If you want a western-style single action revolver for shooting, but aren't too concerned about purist authenticity, but do want the best durability and accuracy, then Ruger Blackhawks are the way to go. These have all coil springs, adjustable sights, magnum frame strength, and yet retain that old west appearance and appeal.
You can get one in blued or stainless, .357 or .45 Colt. Or you can buy a Single Six in .22 LR/.22 Magnum. These are the more expensive option, but you will probably never wear one out or experience a broken part. Ruger even produces a scaled down Remington-styled .22 LR revolver called the New Bearcat which is a joy to own and shoot.
And, of course, there is the Ruger New Vaquero which has the smaller frame like a Colt SAA, authentic Old West sights, and an authentic look and feel, but still has all coil springs inside, just like the Blackhawk.