Not all user serviceable cans are as easy to work with. Conventional k baffles that allow fouling access to the tube (Outback IID, HTA Guardian 22 without the kestrel style nesting baffles, as well as most mono cores other than Sparrow) will need to be cleaned at least every 200 - 500 rounds. If the baffles are lightweight aluminum soda blasting is about the safest most effective way to clean lead off.
For centerfire pistol if you stick to jacketed or cast bullets you can go thousands of rounds without a cleaning but be prepared to persuade the baffles even after a good penetrant soak. High pressure CF rifle cans are claimed to be self cleaning as long as you don't shoot unjacketed ammo in them.
If it weren't for the NFA the market would likely provide cheap 22 cans that would be sealed and disposable to reduce lead exposure. At the price of 22 these days the ammo makers could provide a free disposable suppressor with every case. I have a dream...