You'll need more than a 1/12 twist to stabilize a 77 grain bullet. 1 in 9 most likely.
I'd go with the 22-250. Just yote shooting should not effect barrel life. I'd go with a Savage as they rifle their barrels 1 in 12. Gives you a lot of latitude when selecting bullets. Remington and Ruger use a 1 in 14.
You'll like the range the 22-250 gives you, especially on those that won't come in.
http://www.shilen.com/calibersAndTwists.html
I'd go with the 22-250. Just yote shooting should not effect barrel life. I'd go with a Savage as they rifle their barrels 1 in 12. Gives you a lot of latitude when selecting bullets. Remington and Ruger use a 1 in 14.
You'll like the range the 22-250 gives you, especially on those that won't come in.
http://www.shilen.com/calibersAndTwists.html