for trajectories sake, you can basically say this; however your 22 acts at 100, the hmr does it at 200- that is speed, trajectory and wind drift.
a hmr zero'd at 100 yds, typically drops 2 to 3 inches at 150, and about 7 inches at 200 yds. it also typically raises .5 inches or less, depending on your scope height, at 50 yards, with a 100 yard zero. So you can see, that out to 150 yds, with a low mounted scope, this round shoots extremely flat. Too bad we didn't get the origionally tested 17 hmr stuff tested. I read somewhere, that they were heavier rounds, 20 or 25 grainers, doing 2500 fps, and the 17 grainers were closer to 3000 fps.
now then, anyone who knows me, knows I prefer the 17mach 2, but if cost were not an issue, since I could shoot about 500 dollars a year or more, in the cost of hmr ammo than mach 2, and I did not care about meat destruction, there is no doubt I would shoot the hmr over the mach2.