When you're 65 years old and it's time your grandkid learns how to shoot a pistol, what would you wish you still had? A Bersa Thunder that looks like it was put together and finished in a sweatshop, a Glock with conversion thats too big for a little kid's hands, or a neat cowboy gun with some sentimental value behind it?
I personally would keep it. There are few people in this world kind enough to give guns as gifts.
The Single Six is an example of good workmanship that you wont find in in similarly priced centerfire handguns.
I own two types of guns, permanents and temporaries.
My Ruger 10/22 is a permanant, it was my very first gun and was given to me by my girlfriend. My Sig 228 is a permanant, it was my first centerfire gun and I just love it so much. I have a GP-100 that I bought off a friend for a very good price, I will never sell it because I love shooting it and feel like I would be making money off his loss...you don't do that to friends.
Temporaries are things like my Mossberg 500, Taurus Tracker 970, and Tikka T3. I like them a lot may even shoot them more than some of the permanants. They are the more practical guns, bought for hunting. I wouldn't feel like I lost anything if I got rid of them.
When trying to decide on new purchases, the temporaries get considered in trades and sales to fund other purchases. There's nothing I would want bad enough to sell a permanant. I know if I just wait long enough I'll eventually be able to afford something without selling a permanant.
Everyone, of course, is different. It is easy for me to attach sentimental value to firearms. If you know for sure that you would enjoy something other than the Single Six and don't have any problems getting rid of it then go ahead and get something you like.