"How does a .380 compare to other calibers?"
It is considered the weakest round that is still good for self defense. It is between 9mm and .32 ACP
"Is it very accurate in a small frame auto?"
Yes, because most .380 pistols are blow-back designs and have fixed barrels.
"What do you know about Makarov?"
The pistol or the caliber?
The 9mm Makarov round (aka 9X18 ) is basicly a souped up .380 with a slightly larger diameter bullet. It is not a "True" 9mm, "True" 9mm is .355 caliber. 9mm Makarov is .365 caliber. 9mm Makarov was designed to be the most powerful round that could be used safely in a small blowback pistol. It is not as good as 9mm Luger, but it sure beats .380 ACP. This is the offical round of the russian army, so it must be pretty good
The Makarov pistol itself is made in both .380 and 9mm Makarov. It kinda looks like a walther PP. The 'Mak' is, in my humble opinion, the MOST RELIABLE compact sized semi auto pistol money can buy. I have NEVER seen one jam or have any failure of any kind. I've had a few thosand round thur my Makarov (it's in 9mm Makarov), without any problems whatsoever.
I use my Mak as my carry gun, because I trust it. I know that it will go 'bang' when I pull the trigger. For me, this trust factor is the most important thing when picking a gun for defense...
There are a few other nice things about the Mak. It is very affordable. You can get one for about $150, and you get alot of bang for your buck. It is also very thin, so it's easy to hide. I thought about getting a glock 26 or 27, untill I compared my dad's glock 27 to a Mak. The 2 guns are about the same size, except for the thickness. The Mak is much thinner. The Mak is also more dependable. I've seem the Glock jam a few times, twice in one day even
"What would you use one for?"
Carry. I also carry my Mak when I'm out camping or hiking, but with FMJs. Around town I use Hornady XTPs...
Most .380's are also pretty accurate, so they'd make good target pistols...
Also, due to the fairly low recoil, you could use a .380 to teach someone how to shoot...