Wow, I feel like quite the outcast in this group. When I go backpacking/hiking, I take my Ruger Bearcat in stainless steel. My primary concern is the ability to have food if I run out, get lost, etc. The Bearcat isn't going to replace your favorite rifle, but it can take rabbits and squirrel at reasonable handgun distances. I can put 100 mini-mags in my pack and add a negligible amount of weight. In an absolute pinch it's better than nothing for self-defense, although that isn't something I'm super-worried about, because Vermont has minimal crime in its cities, let alone its trails. As far as critter defense, I do the same level of prevention that all of you surely do.
I feel comfortable with a .22 revolver out in the wilderness, but I won't hate on those who like to have a .44 mag, 1911, or something else. If self defense was my primary goal, I wouldn't pick a .22 lr either.