I'm not a fan of Spyderco anything, and do not care for the flick hole deployment, or their compression lock. They just don't do it for me, and I feel Spydercos are over priced for what you get. But they do seem to work. The one Spyderco I own is a Yojumbo, and I will keep it for what it is, a defensive tool. But I don't see myself ever buying more.
Personally for one handed deployment I've really settled on flippers with a frame lock. They do everything I need, including deploy with a gloved hand. The one thing I'd recommend though is go with a tall blade, like maybe a Wharncliffe or a sheep's foot blade. These blade shapes require a taller handle to accommodate the blade size. The down side is it is wider in the pocket. The up side is it provides more room on the handle to grasp and then flip the knife, without having your hand inadvertently put pressure on the lock bar. I picture this being a little more of a possibility when wearing gloves.
If two handed deployment is a thing, I'd skip the flipper entirely and go for a back lock stile knife.
JMO. Take it with a grain of salt.