+P+ has a bit of a sordid history.
Back when 357Mag revolvers were the standard police sidearm, various attorneys started to demonize the term "Magnum" as "evil", "babykillers", etc.
The response was to load 38Spl ammo at such high pressures it *should* have been called 357, but was in 38-length cases (just a hair shorter) so that on the stand, cops could lie with a straight face: "Oh no, we don't use those evil Magnums, we use nice mild flowery 38Spl".
These "38 +P+" were marked "law enforcement only" because they were unsafe to fire in all but a few 38Spl guns, they were really 357s and if enough got into the non-LEO community the fraud would be exposed.
A lot of the "+P+" autofeeder ammo (mostly 9mm but some 40s&w has been noted) is also marked "law enforcement only" on the box. My take: You can bet there will be private conversations back and forth between the ammo factory and the department armorers as to which loads are really safe for which guns. Not being privy to those conversations, I will not touch "+P+" for love or money, except I'd use 38+P+ in a 357Magnum gun in good shape.
Note: the lie by the cops was a response to lies from attorneys. That still doesn't make it right. They should have confronted the issue head on, instead they dodged it and we're still dealing with the consequences today.
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There is one very dangerous exception to the "+P means 10% over spec max" rule of thumb: 45LC+P. This is WAY over spec, meant for Ruger's ultra-strong 45LC guns or any 454Casull gun. In a decent 45LC gun like a modern Colt SAA or clone, you can drive a 255grain hardcast at around 1,000fps max - 566ft/lbs energy. 45LC+P factory loads can drive a 325grain hardcast at 1,300fps - 1267ft/lbs energy. This is WAY past "+P" in any other caliber. The rounds are often marked "Ruger ONLY!"
Worse: Ruger has recently shipped a "New Vaquero" that's smaller than previous frame sizes and is fine with normal 45LC, not at ALL fine with the monsters. Bufallo Bore has taken a positive step in saying this right on their website:
http://buffalobore.com/ammunition/default.htm