Lots of options here and all have their pros and cons. Older N-frames are great guns and I surely don't have enough of them. Treat them appropriately and they will last a long time. I treat mine as slightly stronger .44Spl's and run them around 1200fps, rather than full steam 1450fps. Both my 29-3 and 629MG are tackdrivers.
My favorites for general purpose use and holster duty are Ruger Bisleys. For me, they are the most comfortable. I have three in .44Mag. A Bisley Vaquero:
A full custom by JRH with oversized six-shot cylinder and Rowen Dall sheep grips:
And a mild custom by David Clements:
For years I thought that Super Blackhawks were uncomfortable to shoot. Come to find out, it was just the factory grips. With these properly shaped stags, it is even comfortable with the Buffalo Bore 340gr +P+ load.
The Uberti Callahan target is a sleek sixgun, barely bigger than a Colt SAA. I treat it about like the S&W's. The cylinder is too short for heavy bullet handloads anyway.
I'm primarily a single action shooter but my favorite as a dedicated hunting sixgun is by far the Super Redhawk. It is comfortable to shoot and well balanced with the optic mounted over the frame, rather than the barrel and you still get to keep your iron sights. The SRH and the custom stainless Bisley above are easily capable of really heavy loads in the 50,000psi range. Long cylinders allow for bullets to be seated out of the case. I've been able to get 330gr LFN's to 1440fps, 355gr WLN's to 1350fps and 405's to 1160fps. The 355gr is far and away my favorite heavy bullet in the .44Mag.
I haven't taken any decent pictures but have been playing with a Dan Wesson over the last year or so. Here it is with a blackbuck I recently took in Texas. Gonna have to do something about the barrel mounted scope as well.