That will depend on YOU.
The CZ-97B is nice, but takes a big hand. Its a big gun. Its like the CZ-75 only large. Great pointability.
The SIG P-220 is nice. Feels good, but limited to 8 rounds.
The H&K .45 is a bit more compact. Also feels good.
The new Ruger P-345 seems pretty nice.
EAA Makes a number of .45s, some compact.
(I've got an ASAI ONE PRO that is about as good as they get, but they're hard to find.)
The S&W 4506 (and variants) are nice, but have a high bore axis that some find offputting.
I'd prefer one with 10 round capacity.