I had to alter my load a bit. .300 Savage, my forever load has been the Speer 150 mag tip over 42 gr IMR4064 with a Rem 9 1/2 primer. At the time I worked the new load for a new rifle last year, 2 of those components were not being made, one hadn't been made for going on 10 years, and my old stock was long used up. My small supply of the existing load were "soft sized" to my M99 and would not chamber easily in my new woods rifle Rem 760.
To the drawing board I went. My brass being tired, I lucked onto 50 pcs Hornady new brass. I could find the Hornady 150 SP, and have used it before, so I went with that. Fed 210 primer as that's what I had, having long used up Rem 9 1/2s. Still had the 4064 though. This is a woods rifle, so I just seated the bullets to the cannelure and worked up for good function and acceptable accuracy with no pressure signs. I landed at the same 42 grain charge, and nice 1.5"groups at 100 yards. Trying to push it 1/2 grain higher got me lesser accuracy. Done deal, 2 deer later, I have my new Forever .300 Savage load until 1 or more of the new components become unobtainable. The sticky lead on the Hornady tips feed better through the 760 than they did the 99. Saving my last stock of the mag tip load for the rare times I bring that rifle out of the safe to hunt.