Yeah... that's what I was thinking when I was reading thirdrails posts... Can you consistantly hit a 2 inch target as quickly as possible under the stress of being under an attack?
If not, I'd entirely drop the notion of planning on hitting the BG in his central nervous system. I think a better plan would to be able to put two shots of expanding HPs from a bullet/caliber combo with adequate penetration into the center of mass and while the BG was (hopefully) slightly disoriented, move in for a head shot.
I'm sure many of us think we will be able to make trick shots while under fire or knife attack, heck... most of us think we can shoot at paper better than we can consistantly, no doubt. But the concept of relying on non-expanding, possibly over penetrating ball ammo in hopes of making a CNS shot... well... it just seems like that should have a good backup plan.
My simple opinion is this: if your 9mm, 357 SIG, 357 Magnum, 40S&W, 10mm or 45ACP gun can reliably feed Rangers, Gold Dots or Golden Sabers, and can get the bullet up to a velocity where they will expand with some level of consistancy (ie over 3" barrel), then that is what will serve most people very well if the need ever arises. It's what most police have the best luck with and it's what basically ever source of 'stopping' data claims is consistantly good.
If your gun is not reliable with HPs or has a 2" barrel, then I'd recommend the heaviest ball or LSWC ammo you can control. I haven't played with EFMJs or PowerBall so I can't comment one way or the other.
Some folks claim over penetration is not a concern... And maybe it shouldn't be... but it is to me. And when the rounds that are less likely to overpenetrate are also the rounds most likely to end the fight quickly... it seems like a no-brainer.
And how many people honestly think that NATO-spec ball 9mm ammo is intended to only penetrate 12" in soft tissue?