The question is ambiguous: a Yes or a NO answer mean the same thing.
Phrase it like this: Is there any justification for infringing the 2nd Amendment?
Dang it, I clicked the wrong button! Can you change a vote???
Whatever.
It should not be infringed.
As many wise and well versed persons have posted, it is not to be infringed, and it is progressivism that decided the interpretation of the Constitution is situational and evolutionary. The way to change the Constitution is established.
Of course the 2nd Amendment is the right to lay claim on the other God given rights. My right to publicly exercise my religion (note, that progressives are currently changing the mindset of the people to believe that the Constitution protects private expression of religion only) and if government takes that right then I have the ability to take arms and say, "No, you have gone to far. I am going to defend this right. Are you going to press me?"
And another thing the 2nd Amendment provides, in a way that I have often considered, is a window into our own soul on how we view are fellow man. If we view our fellow men as Americans, as citizens that have my back, then I am fine with them having a firearm. But, if I view my neighbor as dangerous, unstable, untrustworthy, unethical, immoral, etc., then I want them disarmed (if I am a coward and fearful), and I also want more police to watch these people.
So, how do I view my neighbors? I view them as they should be American. What does that mean? That they will defend with force the U.S. Constitution. That they will mind their own business. That they will be honest. And that they expect me to do the same. If they choose to stick their nose where it doesn't belong, I have the right to defend myself and I will, and they know it and should expect it, there should be no doubt in their mind what they will get. And at the same time, I mind my own business because I expect my neighbor will protect himself and his own with deadly force.
Finally, what should we do with someone that commits a crime with a firearm. Simple. Execute them. Period. Those that use a firearm in a crime not only are saying they will murder to commit the crime but a side effect of the carrying of the firearm is that it undermines people's conviction of the 2nd Amendment.