I had forgotten about this thread. I have a 22 Victory from S&W. The requirement for this thread was that it be a common cartridge that was reloadable. I ended up finding an older 357 Mag Ruger Blackhawk. It is not intended for hunting, certainly not deer anyway. The odd rabbit, groundhog, or possum might be a target for pest control purposes but those are small and I wouldn't be comfortable shooting at them from further than 25 or 30 yards anyway.
The handloads I have for it will generally hold under 1.5" at 25 yards, with most just over 1". That's accurate enough that I know the load and gun aren't the issue. I also recently found a similarly accurate load for one of my 9mm pistols. This new load is a heavy bullet moving less than 1000 fps, so I don't know how it would work beyond 50 yards, but if I wanted a semi-auto, this is a good candidate. It has the advantage of accepting a red dot sight in it's factory configuration. I may one day add something like that to the Blackhawk, but for now I will leave it with the original iron sights.