I think a 460 WBY, even with a good muzzle brake is going to kick the bejeesus out of you. It has 8,000 ponds of muzzle energy with max loads and it is no wimp gun. Just make sure you have a good pad and a good brake. Also, you might want to look into a mercury recoil reducer for the butt stock along with the other measures you take. Now, having said that, I think the 460, if you can manage it, is the king monkey of rifles. It is about the most powerful dangerous game cartridge made.
As for scopes, I think any of the top of the line major brands will hold up. It's not like you're going to shoot 400-500 rounds a year out of the thing. It's one of those rifles you shoot just enough to get used to and proficient with and not sit at the bench trying to tweek the load. Also, one majore necessity with it if you use a scope is a scope with a LONG eye relief, unless you just enjoy being decorated with the famed Weatherby Eyebrow tatto.