Personally I am not as big a BH fan as I once was. I know they are wonderful revolvers but I simply fell head over heels for the RH's. I have them in 41,44, and 45 Colt. They all shoot much better than I can as as far as finding a load, the latest, in 45 Colt has digested everything I have run through it, (lead only at this point) from 200 through 300grs. To be quite honest I haven't found anything yet that it won't shoot pretty darned well.
I find that within normal pressure loads there isn't enough differences between the two, 44, and 45C, to make a hill of beans. To be honest I am finding that I like the 45 more and more simply shooting loads in the 1000 - 1200fps range using weights of around 250grs. Muzzle blast and recoil from either of them in this range is very tolerable, and there are plenty of commercial cast bullets out there as well as plenty of proven molds to pour you own. With the jacketed, well your somewhat at a disadvantage with the Colt as most bullets are made for the 45acp or the 454, so you have very narrow niche to choose from within the Colt's velocity range that will expand properly. Cast however, you have a wide range of not only weights, but styles and hardness as well from the WFN to RN depending on what you thing is. Not to mention being able to size to fit your particular revolver.
I only picked up the Colt due to the fact my grandfather had a Colt Army, and I always like to shoot it as kid, but it was poorly kept and shot plenty of BP loads as such was eroded to the point I will never fire it. It was simply due to sentimental reasons I got mine, and figured I might as well round out my RH collection. In doing so I read up on it before ever buying into which or what type loads I would be shooting. One of the best reads and more convincing to me was Linebaugh's,
The .45 Colt - Dissolving the Myth, Discovering the Potential
In reading through this write up I found that I didn't need to try and load up to the Ruger level loads in order to get good accuracy or productive knock down. In fact I settled on one of his loads using HS-6 and the 260gr RFN as my main go to load and just like he said it shoots wonderful and is very pleasing on the shooter. If I want full throttle power I step up to the 454 and rock and roll.
To be honest I would pick which ever you feel is more your style based upon your typical type of shooting and go for it. Neither are a bad choice.