I think a 22 lr with a well placed shot would take any game in the north America.
It really doesn't matter what I'm hunting, my "go to gun" has it covered,
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DM
I wouldn't want to defend myself with a 22 against a bear, but all this stuff in the Interwebs about how low powered bullets will just bounce of a bear's skull is nonsense. A 22lr will pierce a 1,000lb Brown bear's skull at the right angle. People don't want to believe that an animal that massive can be killed by some jerk-off poacher in a stand with a single shot 22lr, but the truth is that it's really not as uncommon as one would believe. One of my best buddies that used to work up in the middle of nowhere in Alaska has told me multiple times that indigenous people up there poach everything under the sun with 22 rifles.Ya gonna go for bears with that?
I'll grab my Rem 700 in 30-06 for back-up.