Since I'm not fond of Glock ergonomics, I'll steer you toward a 1911 (both Kimber and Dan Wesson offer high-end 1911-A1s in 10mm) or, my personal favorite, the EAA Witness line. They offer a range of 10mm pistols, running from bare-bones Mil-spec "strippers" that start around $350 up to the "Elite" models boasting target triggers, compensators, optics mounts, etc.
They also offer polymer frames, but for 10mm, I'd stick with steel for the recoil absorbtion.