A needle can be lethal with correct placement. That doesn't make it ideal.
What we are talking about here is degrees of likelihood that a given bullet will stop the bad guy from doing what he is doing. All handgun rounds suck. The .25 is probably at the bottom of the list. When you are fighting for your life, you may be wounded, you may have only one hand, (not necessarily your strong hand,) one or both of you may be moving, you may have poor lighting. These are not the circumstances where I want to use a stubby gun with a poor grip to put a bullet through someone's temple.
Would I stand in front of one? Of course not. BUT, say on the other hand, you were faced with a situation where you KNEW you were going to be shot, and you could choose between a 9mm, a .45, or a .25? You are allowed to wear leather and stand at a weird angle. NOW which one seems the least harmful?