I've conducted some impromptu testing with 40, 45 caliber auto pistol rounds, 223 and 5.45 rifle rounds through drywall, denim fabric, and many 1 gallon water jugs. These tests are far from scientific, and only involved firing one bullet apiece from these cartridges, each for the drywall/denim test and the waterjug test. I found that the 60 grain Hornady Vmax bullet fired from the 223 penetrated the denim and the drywall just fine. When a bullet was fired at point blank range into a column of water jugs, the bullet exploded in the first jug, and sent a bb sized projectile into jug number 2.
The 5.45 used a sized down 60 grain Hornady Vmax and performed identically.
The pistol rounds were the most surprising as they too went through denim and drywall just fine, BUT the 40 caliber Hydroshock traversed several of the 1 gallon water jugs, I don't remember just now exactly how many, as did the 45.
I took from this that the 223 is a good HD round, and while it hasn't happened, and likely won't ever happen for me to find out first hand, it seems to me more likely to be able to aim a rifle better than a handgun, so the 1st hit to the "waterjug" torso is more probable.
YMMV