I don't care what caliber you want to shoot, but your choice of hardcast bullets makes me wonder what you are trying to do. If you really want an wilderness gun, there are better caliber choices than .40SW or .45ACP.
What may be good for critters may not be good for humans. Yes, you want penetration, but then you want to maximize tissue destruction for self defense. This is better with a JHP bullet design.
When I hear "hardcast" bullets for SD, all I can think is minimized tissue destruction, non-expansion AND overpenetration danger to others.
I just want it to be capable of being one as i do live in the woods, it would more than likely never ever be used as such i just want the option.
My real woods gun is a Blawkhawk in 45colt loaded with Buffalo Bore's 325 HC load.