in the field, off hand, weaver or isosceles as you'd be shooting defensively, 50 yards is a LONG way to be making hits in the boiler room of a deer.
Agreed, but then again we're not talking about hunting in the wide open . . . . know this is hard to envision in West Texas but, think forest . . . trees. Those well anchored gun rests every few feet. I have regularly killed deer at 75-100 yards using just a tree trunk as a rest with my S&W wheelgun. That's with the factory S&W adjustable sights, not fancy creedmore micrometer click peeps. Haven't lost one yet using the .44 and the longest blood trail I've followed was maybe 40 yards.
If you're better than me and can hit farther out, go for it. I don't have such lofty opinions of my handgun skills, and I'm using a 2X scope on a rifle like handgun in a rifle caliber
Not saying I'm a better shot and I certainly don't have any lofty visions of my handgun skills, but if I can hit deer at even 100 - 150 yards using the .460 that would have meant 3 more deer in the freezer last season from good, but out of range shots I passed on. I think it'll do the job. We'll see.