justin:
Respectfully, IF you are threatened by a dozen assailants, like a gang or something, you are SCREWED, period.
Unless you being attacked by a group, or gang of UNARMED bad guys I don't care how many guns, or how many rounds those guns are loaded with, you are in deep doo-doo, because those ALL of those guys ARE gonna be sending lead in your direction in multiples of what you are sending in theirs..
My understanding is that in WW1 Medal of Honor Winner Sgt. Alvin York had the presence of mind, skill, and mental ability to face off a squad of German soldiers by "picking off the last one first, and working his way to the front"...
I would suggest that unless you exceptionally skilled under such conditions you would NOT be starting at the back and working forward.. You would point and shoot at the nearest targets while at the same time your bladder and sphincter muscle would be yelling "release, release, empty now, empty now" and your "fight or flight" instinct would be yelling "run, shoot, no, run, no shoot" while your heart would be pounding at 500 beats per minute, and your blood pressure would be 220/200, or somewhere wayyyy above average.
So, my opinion is that whatever pistol or revolver you can shoot the best, and have practiced with, and are comfortable shooting is the absolute best one for you.. All things being equal in that scenario a bigger bullet is preferred when you have a choice.. MORE bullets are preferred when you have a choice.
But truthfully I don't think it makes a hill of beans whether you have a 5 shot snubby revolver or an 8 shot 45ACP, or a 15+1 Sig 250, because the shootin's going to be all over with very few rounds fired in a standard confrontation with one or two threats, and if you have the misfortune to encounter a gaggle of threats, or a covey, or a herd of such bad guys as a gang of a dozen the best thing to do is bend over, grab your ankles and kiss your butt goodbye.
Anyway... Even if you had the Sig P250 loaded with top quality 15+1 self defense jhp rounds it's entirely possible (Murphy's Law applies here) the bad guys might consist of SEVENTEEN vs !5+1 and you are still SOL, plus that 17th guy is gonna be really pissed after watching you gun down his 16 buddies..
Just personal opinion, no offense.
Jesse