Just so you know, the CZ is no less American than the Savage. Both companies have American facilities and both companies are importing those rifles. The CZ from the Czech and the Savage from Canada. If I had to look at a Country with a rich background in firearms manufacturing, the Czech would fall higher on my list than Canada.
Of the three, the Ruger would probably be my bottom pick. They seem to be hit or miss. Some shoot well, some shoot well after a bit of work, and some require a LOT of work. If they were priced where the 10-22 is priced, I'd buy a bunch and have work done to them. I like the action and magazine. But, they are too expensive for the gamble, in my opinion.
The Savage is a good buy. The base models are all fairly cheap. I have troubles spending for their more expensive lines, as the stocks are all Boyd's stocks which run about $100. I'd be inclined to buy a base model and then a new stock rather than pay a premium to have it come with the same stock from the factory. The accutrigger is decent. If you haven't felt a better trigger, it seems great. When you do get to play with better triggers, it just feels ok. Certainly more than usable. Accuracy seems to be pretty good, though with the price point they come in at, CQ can be hit or miss and some rifles more picky than others. If budget mattered, I'd go Savage as you just can't beat the price for $200-$250 for their base models.
The CZ is the rifle you buy with intentions of handing it down. That certainly isn't to say that the Savage wouldn't last multiple generations, but the feel, fit, and finish of the CZ are of the quality of something you would be proud to hand down. They tend to shoot pretty well with a wide range of ammo. The triggers on the 452 and 455 are only adjustable for a little bit of weight from the factory. Of the two I have, one had a lot of creep and the other was very very crisp. Shimming the creep out of the trigger is fairly easy and cheap, though an aftermarket adjustable sear is available from a few companies if you rather that.
All of these rifles are ones that I would say need work to come close to their potential. The Ruger could take as little as a nicer trigger or as much as a new barrel. Now that the barrels are threaded it's a little more effort to swap a barrel. If you go base model Savage get one with the accutrigger. Then you would be looking at a new stock and maybe a new spring or cut spring for the accutrigger, if you wanted a lighter pull. The CZ typically only needs a little help on the trigger. Either a shim or a new sear, depending on preference, as well as a lighter spring if less trigger weight is desired.
They seem to all benefit greatly from bedding. I have yet to see a sub-$500 rimfire rifle that had a good stock to action fit from the factory. I've bedded all of the ones I plan to shoot much for accuracy and all have become much more consistent in their shooting after bedding.
So my ranking would be to buy the Ruger if you like to gamble, are looking for a project, or have the ability to shoot the rifle ahead of time.
Buy the Savage if budget is an issue.
Buy the CZ if the top two suggestions don't apply.