For eating sized game, a good hunter should be able to work closer than 500, I've only ever shot once at a deer past 400 and that was because he was dragging a shattered rear leg from someone else's "hunt" and I knew I couldn't get to him in time, so the 300wm barked and he dropped, don't really use that one much anymore, but varmints at longer ranges are pretty common around here, just 2 weeks ago I ranged a yote at 525 and couldn't get him to come in. He didn't run off. However, my rifles all pack more heat out there than the Grendel. I don't worry about the bullet drop that everyone talks about, that is the easy part. Still having the velocity required to make your bullet do what it's supposed to is my issue.