I don’t feel the legacy of my grandfather firing any cartridge. And my idea of the 2nd Amendment is our ability to shoot any cartridge.
This type of argument is so old and stale, and somehow we always get here.
As to the OP question, 45ACP is a great defensive round, as is 10mm, 40S&W, 357 Mag, 38 Special, and 9mm. Personally, I choose 9mm because I can train with it twice as much than with 45ACP. Also, the fact that if I’m caught in a scenario (movie theatre, church, mall, etc) where there’s potential for multiple perpetrators or hardened perpetrators and I have no way of escape or loved ones need defended then I’m going to appreciate a handgun with 15+1 (G48 in 9mm) than one that is 7+1 (1911 in 45ACP). Both of these firearms are similar in size, but not weight, the Glock being lighter.