I am not considering any other powders, as I have loads that I have tailored to my guns and my needs, with five or six different pistol calibers that I regularly load for using Universal
My situation is a bit different than yours. I have 'zero' favorite loads with Uni, but years ago, I happened across Kegs of Uni for 50 cents on the dollar. Even though I'm 'not a fan', I bought all they had. Sold some, but I'm still sitting on 2 lifetimes worth, slowly working through it with the Lee PPM here and there.
(It would be nice if press manufacturers would put warnings on their drops that indicate 'May not work well with all powders", but I reckon Marketing decided it wouldn't be a good idea. LOL! )
When you get tired of futzing with it, you can always use your Lee drop to charge off the press. It adds yet another step to the process, but it's lots less frustrating.
Loaded some 9mm w/W244 on the AP last night. Powder drop worked flawlessly. 322, 335, Sport Pistol, HP38/231, "CFE"-anything, TAC, Bullseye, Tightgroup, WST, Sta-Ball 6.5 and some others I've failed to mention all work flawlessly.
But, it could always be worse,,, Stick powder (Varget H4350, RL-15, etc) in the LNL drop makes Uni look like the proverbial 'walk in the park'.