IIRC Eastwood's character claimed the 44 Mag was the most powerful handgun in the world so logically since "wildcats" were in the world they would be included. The better argument would be the undefined termed "powerful" as that gives enough wiggle room to drive a combine with a 45 foot header through.
In the original script the bad guy looked back at Clint and said with a smirk "Haven't you ever heard of the .454 Casull that has been around since 1959?" But I guess that part got cut out in editing. LOL!