It all relates back to Claude Clay's scenario in Post #31. If you have known-loaded guns with assumed-loaded guns (aka, probably unloaded), you might want to have an easy way to quickly identify the known-loaded guns(s) in case of emergency. You don't have that problem with your EDC because that's what it's there for. In an emergency, you don't want to reach into your safe (or walk into your safe room) and take too much time identifying which weapons are known to be loaded. Of course you assume every weapon is loaded in routine handling, but in an emergency you want extra assurance that your weapon is loaded. A holster or a green rubber band can help provide that assurance.
I don't practice this because I only have four handguns, and except for between strings of fire two or three Saturdays a month, they are always loaded.