Just my 2¢...
About 1 1/2 years ago, after a successful deer season with my Uberti .44 Special, I got it in my head I wanted to try the 45 Colt. So, I picked up a 4 3/4" New Vaquero and unintentionally a 4 3/4" Model Uberti Cattleman.
Although the Ruger was pretty good for the most part, I had personality conflicts with both of those revolvers. So a few months I bought a new 5 1/2" Uberti Bisley and what a lady she is!
I have tons of chronograph data, but it's in the shop so I'll post a couple of pictures and the data I remember. I'll post some pictures of targets below so you can get an idea of what "accurate" means to me. Please keep in mind rarely, almost never shoot from a bench and all these targets will have been fired from a sitting, back supported position.
For bullets I have a Lee 255 RF mould, an NOE 454424 4-cavity mould, an RCBS 44-255 mould and a Miha that casts a copy of the RCBS 45-270 and the ability to cast four different type HP's.
The NOE, a very well made mould, casts beautiful, consistent bullets but for some reason I get very inconsistent accuracy. The Lee is a total piece of junk that requires hand alignment of the blocks because one of the alignment pins fell out shortly after I began using it. It casts pretty good bullets that are accurate though. The Miha likewise is a superbly built mould that casts flawless bullets that shoot well. The RCBS however is the shining star. It drops bullets in the 263 - 265 gr. range and just shoots lights out. It may be no coincidence that my RCBS 44-250KT mould also casts bullets that are extremely accurate.
Anyhow, 700-X, Unique and Blue Dot pretty much became my go-to powders. With 700-X I use in 6.5 gr. Some sources indicate this load is over maximum, but Brian Pearce published it in his 14,000 psi data under a 280 gr. bullet, and at 6.4 grs. under a 250 gr. bullet to duplicate the original load. Anyhow the load always shot good for me in any 45 Colt revolvers.
With the RCBS bullet:
Unique in any charge from 8.0 - 9.0 shot very well.
Finally Blue Dot. It and the bullet from the RCBS mould make a fine, fine pair. My Alliant 2008 Loading Guide shows 12.9 grs. as a max with a 250 gr. lead SWC, so I worked up to loads in that range using the 265-ish gr. bullet. Velocity was in the 1000 fps range, maybe a hair less, and accuracy was outstanding with 50 yd. groups usually about the size of a mans fist. I also loaded some of these over the same charges of BD. Not quite as accurate but plenty good for 50 yds. Unfortunately I haven't snapped any pictures of groups from Blue Dot.
Maybe this will help some.
35W