Okay, I used to lust after the New Advantage Arms, which is similar to the Mossberg Brownie, I think. There was a smaller version of the COP derringer in .22 WMR ... which makes for a whole slew of 4-barrel 22s made well after the pepperbox era.
Along the same lines, is
HJS's Frontier Four derringer ... which is going for $1000 these days?
The American Derringer Model 1 isn't inherently odd; it's just weird to chamber a .22 LR on the same frame that can be chambered for .45-70 Government.
Does anyone else sort of like the
Springfield M6 Scout Pistol? I just can't get over loving the way it looks ... like an elegant yet dangerous dinosaur.
I'm pretty sure most
zipguns are .22 LR. I wouldn't recommend trying to fire or buy one though....
Okay, this isn't strictly a handgun, but it's small, and it is
DEFINITELY an oddball. Scroll down to XM1822. Let me say two things: (a) that product should not exist and (b) I MUST HAVE ONE. (Okay, I'm sure I'll never go through the legal rigamarole to get a darn grenade launcher, but sometimes when I see things, I want them. Though shalt not covet thy neighbor's wife's grenade launcher accessories.)
I've seen .22-caliber knives before, but
this is the only one I can find.
(I saw a picture of a purported .22-caliber bayonet fixed to an AR-15, described as "a gun with an attached knife that is also a gun" ... but I think it was a joke. Of course, my first thought was ... I wonder if you could sight-in the bayonet to use your standard iron sights??)
I think the suppressed version of the High Standard (WWII) and Ruger (Vietnam era) pistols are pretty odd ... another legally complicated choice.
Also, I think there was a pistol variant (barely!) of the Calico LWS chambered for .22 LR. Tell me how
that thing survived during the assault weapons ban!