I agree with those that advocate large revolver rounds. I am a big advocate of the 10mm. I have a customized glock 20. Great night sights and nice roughed up grips and a fantastic trigger. I love it.....for certain things. Bear and large dangerius animals arent one of them. Hunt enough big things and guns like the 10mm and 357 underwhelm you rather dramtically. Ive killed buffalo with a 41 mag handily. I got to sneak in stealthily and pick perfect angles and take the big beasts down. Change that to a head on charge scenario and i will take my 454 44 460 or various 500’s thank you very much. I will take a heavy 44 mag on up with one or two well placed shots over a 10mm no matter what the scenario. Maybe if i was facing an aggressive pack of several wolves would i take the 10mm. Interesting case here, but i had a buddy that was hunting a watusi bull. Hes not a real experience shot. After a few botched placement shots from his guide gun and a few misses. We pursued. Watusi can get salty. Imho much quicker than waterbuff or other bovines. It turned to face us from the mesquites. My buddy was out of bullets for the guide gun drew his srh 454 and aimed for the brain. I, and one hunter had him backed up with our revolvers. The bull was starting to come forward and my buddy fired and pulled the shot horribly out of fear and pulled it into the watusi’s left shoulder. It busted the shoulder and the bull went down and was finished off. It was about 20 yards away. My buddy isnt a great shot but isnt a bad shot. He hasnt faced this down before and he panicked. If you dont train or put yourself in stressful situations this can happen to anyone. I find it very handy to run very high horsepower rounds. Same thing with my cape buff this summer. Also with my sons lioness in 2013 in south africa. Never felt better he put a barnes 275 from a 460 through the chest. On video the lion turns to come and crumples before she gets going. This is what happens in real situations and had that lion gotten going i think itll cover the 25 yards rather quickly. Youre not getting of many shots for sure and you need to crush the animal quickly with less than perfect shots. Not the best domain for a 10mm imho based on experience. What kills a 200lb bear definitively and the 500 to 600lb variety of black bears are a whole different animal.