My 625MG is in .45colt. No need for moon clips. Uses conventional speed loaders. No need for tedious de-mooning. Also, capability of a little bit warmer loads and significantly heavier bullets.
I do have a "shaved" Webley MK II. It uses moon clips, but not able to use factory level .45acp. It's a joy to shoot with a target load with 200 gr SWC. Ejection really is just a "snap" as the ejector reaches its limit, it snaps back into the cylinder allowing the ejected cases and clip to fall away.
Knowing the limitations of the 625 in .45acp going in, I believe you'll be a satisfied owner. I've owned a Ruger RedHawk (too heavy!), Black Hawk (too heavy, not accurate), new model Lipseys special BlackHawk (couldn't warm up to the grip).
Finally, ran across the 625 which is what I really wanted.
I believe if I had a 625 in .45acp, I'd invest in some .45AR brass.
My favorite bullet for the 625mg is the Lee 255gr RFN. I load it to duplicate the original black powder load @ ~950fps (9.0 Unique)
After 140yrs, it still WORKS. Completely penetrates deer.... Front to back!
Jeff Cooper was right. The .45acp really is enough gun.
Added; remember there are several "generations" of Mod 25's and 625's. Some have a shoulder in the chamber allowing the cases to headspace on the case neck. These can be fired w/o clips. Most however have straight through bored cylinders and require AR brass or clips. It's easy to tell by opening the cylinder and looking in the chambers (yeah, I know Smith calls them charge holes...) to see if they're bored through or have a stepped down throat.