My wife shocked me with my first S&W over seven years ago - a new 625-7 MG in .45 Colt (top, below). It joined a mix of Ruger SAs and one DA in .45 Colt. It quickly displaced my 7.5" .454 SRH as my DA .45 Colt - I tried to wear it out, until I got a 4" 625-8 (.45 ACP) almost seven years back. I later added a new 5" SS Redhawk in .45 Colt, a friend and I ordering one each locally as we heard they were being discontinued. Mine had burst casting bubbles between the cylinder exit bores - and went back within days. Sadly, I got to experience the long drooping extractor causing the ejector to skip over a rim, jamming the revolver - and requiring three hands to clear. It did the same when it came back - and, although 'tweaked' by Ruger, it's long trigger pull, if enjoyed slowly, would occasionally result in a ftf - even with Federal primers. My softer triggered 625MG never gave a ftf with Fed primers. When I traded a 5.5" SS Bisley for another MG, an older but LN 625-6 (bottom, below), the RH's days were numbered. I've never had an ejector star skip over a rim in either 625MG - and they've seen lots of use.
The 25/625 barrel, frame, and cylinder were designed - and hardened - for the 22 kpsi .45 ACP round, not the .45 Colt and it's 14 kpsi rating. Linebaugh and others have shot the 25/625 families at .45 Colt plus levels for years. I stay close - or within - the 14 kpsi rating - and still get near 900 fps for either a Speer 250gr Gold Dot (#4484 - when I find them!) or a 255gr LSWC. Of course, even a 200gr LRNFP at 830 fps, pretty mild, exceeds 'major' power factor, if you are into such. The .45 Colt MGs are fine in wood grips at any normal power rating.
Not in production, you can usually find a LNIB 25/625 MG in .45 Colt for less than a new 4" RH in .45 Colt. YMMV.
Stainz
PS My biggest bone to pick with S&W is the laser-etched writing on the barrels, which I've nearly erased cleaning them over the years.