I grew up out in West Texas and my Grandparents lived in Midland Odessa for a time. I know many people that live out there love it, but I always referred to it as Slowdeatha. I haven't been out there in a while, but since the oil boom isn't booming out there like it was I don't think their economy is nearly what it used to be. Plus the water taste awful.
San Angelo was a nice place to live, Abilene is a nice little town, I love Fort Worth (living here since college), Dallas is not too bad if you like that sort of thing, and Houston is pretty much an armpit (heat + humidity). Although, being from Florida you are probably used to the humidity. Austin is a liberal mecca. They have t-shirts printed up that say "Keep Austin Weird" for a reason.
Of course, if I was independantly wealthy, or retired, I would live in the Alpine/Big Bend area, or the Southern tip of the Texas coast in a heartbeat. Big Bend is beautiful, sparsely populated, and your neighbors are people like Art. Actually being in Terlingua, he would be your neighbor.