Only one I have any experience with is the Neos.
No complaint on the grips, fits me comfortably, and the sweetheart seems to handle and shoot it easily as well.
Safety is a pain in @55! Located too far back to be comfortably engaged or disengaged with the gripping hand; angle of the grip places your thumb too far forward. Pretty much a 2 hand operation for me, as my thumbs just don't go there, unless I release my grip on the pistol. I picked up a holster for mine, but find the safety in the Fire position to often when carrying it, to be comfortable with a round chambered while holstered. If you buy a holster, which given frame size and barrel length they can be a little tough to find a holster for, be certain it clears the safety, or clear your chamber every time you holster it!
Likewise, I'm not fond of the clip release button's location.
1.) It's on the opposite side of the gun from my other auto pistols.
2.) It's located precisely where the safety on my 22 rifle (
and several other guns I own) is located, just rear and high of the trigger. And, thus on more than one occasion, I have dropped the clip thinking I was releasing the safety, out of habit.
Both are minor inconveniences, just take some getting used to when I haven't shot it in awhile. Otherwise... I absolutely love it!!
The rail on the barrel gives the U22 a weight and feel that is very similar to that of my 45 ACP. And, since the U22 is a whole lot cheaper to shoot, and I shoot it a whole lot more often, it's really kinda nice to have that weight and feel there all the time.
Take down is a breeze! And, you do have to love a gun that you don't have to go to the toolbox to tear down!!
Swapping barrels out likewise takes less than a minute, and there are several to choose from... 4 1/2", 6", 9", and the 16" that comes with the Carbine kit. Finding them, with exception to the Carbine kit, is however another story!! I have had no luck locating a 4 1/2" in stock to date! (
Which reminds me, I need to check on that again, it's Christmas, and Santa needs to come see me!! 
)
Accuracy is fantastic for a 22 handgun. While I have seen a little difference in some ammo used, it seems to perform reasonably well with most. The U22 and I both love the Remington Hyper-Velocity rounds.
And, I've had no problems with feed or ejection out of anything I've run through it.
On a scale of 10, I'd give it an 8.5 - 9. It's Affordable, Accurate, Reliable, Comfortable to shoot, extremely Adaptable, and easy to work on. Can't ask anymore than that out of a gun honestly.
