I'm sorry, IMO the concepts that you are describing are not safe or realistic if intending to build a working gun that's made to fire.
While in theory, almost anything can be made to fire once or a limited number of times. that's not what safe or responsible BP gun building is about.
Since I have no idea about the quality, size or weight of your intended parts, I have no basis to make helpful recommendations.
But individual threaded breech plugs are generally the only accepted method for sealing hollow .44 barrels.
There are screw barrel pistols that are loaded by unscrewing the barrel, but a solid steel receiver is still an important part of the concept of safety.
Below is a photo of the breech plug for a flintlock rifle, which pretty much has the same design as a small .45 Derringer pistol would have.
It's easy to see the amount of safety that's built into it by being made with such a large amount of quality steel.
View attachment 940818
https://americanlongrifles.org/forum/index.php?topic=52089.0